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T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
The human body’s own immune system has nearly limitless capacity to detect abnormalities. This ability is achieved by the related structures of two molecules, immunoglobulins and T cell receptors (TCR).
The TCR, a defining structure of T cells, is a transmembrane heterodimer consisting of either an alpha and beta chain or delta and gamma chain linked by a disulphide bond. Within these chains are complementary determining regions (CDRs) which determine the antigen to which the TCR will bind. TCRs activate the T cells in which they reside leading to a plethora of immune responses. Harnessing the power of this response and of TCR specificity is leading to a new generation of extremely promising immunotherapies.
